受託研究機構
McLaughlin 研究院在小鼠遺傳學方面的重大貢獻受到廣泛認可。該研究所主要透過動物模型、細胞系統及生物化學和分子生物學，在臨床前和研究中模擬人類的常見疾病。目前McLaughlin 研究院的動物資源中心的能力可幫助滿足轉基因小鼠和生物醫學探索的需求。
動物資源中心
McLaughlin 研究院的動物資源中心為一先進設施，專門為在安全、清潔的環境中飼養小鼠而設計，該中心的建設皆符合研究動物設施運營所需的嚴格監管標準。自 1996 年以來，動物資源中心已獲得實驗動物護理評估和認證協會 (AAALAC) 的全面認證。
轉基因設施
提供的服務包括：
- CRISPR/Cas9基因編輯
- 精子和胚胎冷凍保存和恢復
- 原核注射
- ES細胞注射
- 體外受精
- 將小鼠品系重新衍生至無特定病原體狀態
小鼠遺傳學
McLaughlin研究院善用自身在哺乳動物遺傳學的優勢。McLaughlin研究院於 1995 年獲得實驗動物護理評估和認證協會 (the Association for Assessment and Accreditation of Laboratory Animal Care) 的全面認證，目前研究院中約有 15,000 隻實驗小鼠。研究院配備的小鼠專用動物設施可高效進行動物護理，有效減少獸醫監督的需求，進而降低每日成本。McLaughlin研究院中的鼠群被保護在動物屏障設施中，免於病原體的侵擾。負責小鼠的動物技術人員也積極參與該研究所的研究項目，建立起飼養員與小鼠的連結，進而培養對於小鼠的責任感。
Contract Research
The McLaughlin Research Institute is widely recognized for its significant contributions in mouse genetics since 1954. A large part of the preclinical and basic research focus at the Institute is on modeling common human disease through animal models, cell-based systems and biochemistry and molecular biology.
MRI’s Animal Resource Center currently has excess capacity over current faculty needs that is now available to help meet the demand for biomedical discovery and transgenic mouse services.
Animal Resource Center
The MRI Animal Resource Center is a state-of-the-art facility, designed specifically to house mice in a safe and clean environment. The ARC facility was designed and constructed to meet exacting regulatory standards required for the operation of research animal facilities. The ARC has been fully AAALAC accredited since 1996.
Transgenic Facility
SERVICES OFFERED
- CRISPR/Cas9 gene editing
- Sperm & Embryo cryopreservation and recovery
- Pronuclear Injection
- ES Cell Injection
- In Vitro Fertilization
- Rederivation of mouse lines to specific pathogen free status
Contract Research
The McLaughlin Research Institute is widely recognized for its significant contributions in mouse genetics since 1954. A large part of the preclinical and basic research focus at the Institute is on modeling common human disease through animal models, cell-based systems and biochemistry and molecular biology.
MRI’s Animal Resource Center currently has excess capacity over current faculty needs that is now available to help meet the demand for biomedical discovery and transgenic mouse services.
Mouse Genetics
The research programs at McLaughlin Research Institute take advantage of the Institute’s historical strength in mammalian genetics. The animal facility is designed exclusively for mice, allowing efficient animal care, fewer demands for veterinary oversight, and, consequently, per diem rates lower than most other institutions. The mouse colony is maintained as a barrier facility and is free of viral pathogens. Animal technicians are active participants in the Institute's research programs, providing services such as tissue sampling, neurological testing, surgical procedures, and record keeping. This provides relief from the tedium of cage changing for the caretakers and develops a sense of responsibility for "their" mice. Current census is approaching the capacity of approximately 15,000 mice. McLaughlin Research Institute was fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care in 1995.
